Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties

Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties.

Celecoxib spherical agglomerates were prepared with polyvinylpyrrolidone (PVP) using acetone, water and chloroform as solvent, non-solvent and bridging liquid, respectively. The agglomerates were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), IR spectroscopic studies and scanning electron microscopy (SEM). The IR spectroscopy and DSC results indicated the abs...

Spherical Crystallization of Zaltoprofen for Enhancement of Micromeritic Properties and Dissolution Rate

The present work deals with the spherical crystallization process by Spherical agglomeration method applied to Zaltoprofen, a novel NSAID drug. The object of present study was to prepare and characterize the spherical agglomeration of water insoluble non-steroidal anti-inflammatory drug. Zaltoprofen spherical agglomerates prepared with poly ethylene glycol, which is hydrophilic polymer by using...

soluplus®; a novel excipient to improve dissolution rate of poorly water soluble drug, celecoxib

Enhanced Solubility and Dissolution Rate of Raloxifene using Cycloencapsulation Technique

The aim of this study was to improve the water solubility of raloxifene by complexing it with sulphobutylether-β-cyclodextrin. Inclusion complexation in aqueous solution and solid state was evaluated by the phase solubility diagram, powder X-ray diffractometer, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, scanning electron microscopy, hot stage microscopy and transmissio...

Design of Agglomerated Crystals of Ibuprofen During Crystallization: Influence of Surfactant

Objective(s) Ibuprofen is a problematic drug in tableting, and dissolution due to its poor solubility, hydrophobicity, and tendency to stick to surface. Because of the bad compaction behavior ibuprofen has to be granulated usually before tableting. However, it would be more satisfactory to obtain directly during the crystallization step crystalline particles that can be directly compressed and...